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The inhibitory effect of intraventricular administration of serotonin on spontaneous motor activity of rats.

Authors
  • Green, R A
  • Gillin, J C
  • Wyatt, R J
Type
Published Article
Journal
Psychopharmacology
Publication Date
Dec 21, 1976
Volume
51
Issue
1
Pages
81–84
Identifiers
PMID: 827778
Source
Medline
License
Unknown

Abstract

Spontaneous motor activity was studied following injection of 1, 10 and 50 mug of serotonin (5-HT) into the lateral ventricle of chronically cannulated rats. During the first 15 min, the rats receiving the higher doses of 5-HT showed significant decrements (P less than 0.01) in motor activity compared to saline controls. No activation was observed in either group. After 20 min, no significant differences for any treatment condition compared to saline controls were observed. It is concluded that a principal effect of directly increasing brain 5-HT concentration is to decrease activity. Possible mechanisms for this effect are discussed.

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