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Inhibitory effect of intrahippocampal noradrenaline and isoprenaline on rabbit EEG.

Authors
  • Smiałowski, A
Type
Published Article
Journal
Polish journal of pharmacology and pharmacy
Publication Date
Jan 01, 1983
Volume
35
Issue
3
Pages
249–255
Identifiers
PMID: 6622304
Source
Medline
License
Unknown

Abstract

Influence of noradrenaline, or isoprenaline injected into the dorsal hippocampus on electroencephalogram and behavior of rabbit was studied. The injections increased the participation of slow waves and spindles in cortical EEG, suppressed hippocampal theta rhythm and blocked the spontaneous locomotor activity. The inhibitory effect of isoprenaline was reduced by intrahippocampal pretreatment with propranolol or sotalol; the beta-blockers injected intrahippocampal induced EEG arousal and behavioral excitation. These results indicate an inhibitory role of noradrenaline and isoprenaline in the hippocampus of rabbit.

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