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Inhibitory effect of bombesin and SMS 201-995 on DNA synthesis in the rat thyroid lobes incubated in vitro.

Authors
  • Lewiński, A
  • Sewerynek, E
  • Wajs, E
  • Baranowska, B
  • Zerek-Mełeń, G
  • Kunert-Radek, J
Type
Published Article
Journal
Biochemical and biophysical research communications
Publication Date
Jul 31, 1991
Volume
178
Issue
2
Pages
520–525
Identifiers
PMID: 1859412
Source
Medline
License
Unknown

Abstract

The effects of 4-h incubation in the presence of bombesin on the incorporation of [3H]-thymidine into DNA of the rat thyroid lobes, collected from animals treated in vivo with a long-acting somatostatin analog (SMS 201-995) or with 0.9% NaCl, were investigated. It was shown that not only in vivo injections of SMS 201-995, but also, unexpectedly, in vitro incubation with bombesin inhibited [3H]-thymidine incorporation. The two examined substances did not reveal any additive action in their inhibitory effects on the thyroid growth.

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