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Inhibitory Effect of 5-FU loaded ultrasound microbubbles on Tumor Growth and Angiogenesis.

Authors
  • He, Yang1
  • Zhang, Yue1
  • Qin, Hai-Ying1
  • Gu, Dong-Yue1
  • Lu, Xiao1
  • Hu, Jin-Xi1
  • Ye, Wei-Liang2
  • He, Guang-Bin3
  • 1 Department of Ultrasound Diagnosis, Xijing Hospital, Fourth Military Medical University, Xi'an 710038, China. , (China)
  • 2 Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an, 710032, China. Electronic address: [email protected] , (China)
  • 3 Department of Ultrasound Diagnosis, Xijing Hospital, Fourth Military Medical University, Xi'an 710038, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Bioorganic & medicinal chemistry letters
Publication Date
Sep 05, 2020
Pages
127534–127534
Identifiers
DOI: 10.1016/j.bmcl.2020.127534
PMID: 32898694
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The anti-neovascularization treatment is one of the effective strategies for tumor molecular target therapy. At present, the target and effect of the anti-neovascularization treatment is limited, and it is urgent to establish a new vascular targeting strategy to effectively treat tumors. In this work, we used high intensity focused ultrasound (HIFU) combined with targeted microbubbles to establish a molecular targeted ultrasound response microbubble for neovascular cells. Furthermore, the effects of drug loaded microbubbles on neovascularization and tumor cells were studied. The tumor vascular targeted and ultrasound-responsive microbubbles of [email protected] were prepared by the thin-film dispersion method. The size and zeta potential of [email protected] was about 1248 nm and -9.1 mV. [email protected] released 5-FU showed an ultrasound-responsive manner, and had better vascular-targeting ability. Furthermore, the [email protected] showed the strongest cytotoxic effect on HUVECs or HepG-2 cells and can be effectively internalized into the HUVECs cells. Thus, [email protected] combined with HIFU can be considered as a potential method for antitumor angiogenesis in the future. Copyright © 2020. Published by Elsevier Ltd.

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