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Inhibitory Activity of Alkoxyalkyl and Alkyl Esters of Cidofovir and Cyclic Cidofovir against Orthopoxvirus Replication In Vitro

Authors
  • Kathy A. Keith
  • William B. Wan
  • Stephanie L. Ciesla
  • James R. Beadle
  • Karl Y. Hostetler
  • Earl R. Kern
Publisher
American Society for Microbiology
Publication Date
May 01, 2004
Source
PMC
Keywords
License
Unknown

Abstract

A new series of ether lipid esters of cidofovir (CDV) were evaluated against vaccinia and cowpox viruses. Activity was dependent on number of atoms in the alkyl or alkoxyalkyl chain, the linker moiety, and the presence of a double bond in the alkoxyalkyl chains linked to the phosphonate moiety of CDV.

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