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Inhibitory action of azelastine on cytokine production from human peripheral blood leukocytes in vitro.

Authors
  • Konno, S
  • Adachi, M
  • Asano, K
  • Matsuo, S
  • Okamoto, K
  • Takahashi, T
Type
Published Article
Journal
Life Sciences
Publisher
Elsevier
Publication Date
Jan 01, 1993
Volume
53
Issue
13
Identifiers
PMID: 8366765
Source
Medline
License
Unknown

Abstract

Effects of azelastine (AZ) on human peripheral blood leukocytes (PBL) in culture were examined. Addition of 10.0 micrograms/ml of AZ resulted in a marked inhibition of PBL blastic activity, but lower concentrations (1.0 and 0.5 microgram/ml) had no demonstrable suppressive effects on the activation. Interleukin (IL)-2, IL-3 and IL-4 production from PBL in response to Concanavalin A stimulation was also strongly suppressed when the cells were cultured in the presence of AZ. This suppression was observed even when lower concentrations (1.0 and 0.5 microgram/ml) of AZ were added to cell cultures.

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