Inhibitory action of azelastine on cytokine production from human peripheral blood leukocytes in vitro.
- Published Article
- Publication Date
Jan 01, 1993
Effects of azelastine (AZ) on human peripheral blood leukocytes (PBL) in culture were examined. Addition of 10.0 micrograms/ml of AZ resulted in a marked inhibition of PBL blastic activity, but lower concentrations (1.0 and 0.5 microgram/ml) had no demonstrable suppressive effects on the activation. Interleukin (IL)-2, IL-3 and IL-4 production from PBL in response to Concanavalin A stimulation was also strongly suppressed when the cells were cultured in the presence of AZ. This suppression was observed even when lower concentrations (1.0 and 0.5 microgram/ml) of AZ were added to cell cultures.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/8366765