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Inhibitors of the cleavage of aclacinomycins.

Authors
  • Gräfe, U1
  • Dornberger, K1
  • Fleck, W F1
  • Schumann, G1
  • 1 Central Institute of Microbiology and Experimental Therapy, GDR Academy of Sciences, P.O. Box 73, DDR-6900, Jena, GDR.
Type
Published Article
Journal
Biotechnology Letters
Publisher
Springer-Verlag
Publication Date
Dec 01, 1987
Volume
9
Issue
12
Pages
837–842
Identifiers
DOI: 10.1007/BF01026192
PMID: 28247133
Source
Medline
Language
English
License
Unknown

Abstract

The reductive cleavage of the aclacinomycins A (I), Y (II), and B (III) by intact mycelia or subcellular fractions of the producer strain S. spec. AM 33352/F43 is suppressed in the presence of uncouplers, complex-forming agents, detergents, and some metal anions such as chromate. Increased concentration of the latter in complete cultures caused rearrangement of I to III.

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