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Inhibition of virus production in JC virus-infected cells by postinfection RNA interference.

Authors
Type
Published Article
Journal
Journal of virology
Publication Date
Volume
78
Issue
13
Pages
7270–7273
Identifiers
PMID: 15194803
Source
Medline
License
Unknown

Abstract

RNA interference has been applied for the prevention of virus infections in mammalian cells but has not succeeded in eliminating infections from already infected cells. We now show that the transfection of JC virus-infected SVG-A human glial cells with small interfering RNAs that target late viral proteins, including agnoprotein and VP1, results in a marked inhibition both of viral protein expression and of virus production. RNA interference directed against JC virus genes may thus provide a basis for the development of new strategies to control infections with this polyomavirus.

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