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Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice.

Authors
  • Huang, Junhao1, 2
  • Furuya, Hideki3
  • Faouzi, Malika1
  • Zhang, Zheng1, 4
  • Monteilh-Zoller, Mahealani1
  • Kawabata, Kelly Galbraith5
  • Horgen, F David5
  • Kawamori, Toshihiko3, 6
  • Penner, Reinhold1, 3
  • Fleig, Andrea7, 8
  • 1 Center for Biomedical Research, The Queen's Medical Center, John A. Burns School of Medicine, University of Hawaii, 1301 Punchbowl St., Honolulu, HI, 96813, USA.
  • 2 Present Address: Guangdong Provincial Key Laboratory of Sports and Health Promotion, Scientific Research Center, Guangzhou Sport University, Guangzhou, China. , (China)
  • 3 Cancer Biology Program, University of Hawaii Cancer Center, 701 Ilalo St, Honolulu, HI, -96813, USA.
  • 4 Present Address: Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China. , (China)
  • 5 Laboratory of Marine Biological Chemistry, Department of Natural Sciences, Hawaii Pacific University, Kaneohe, HI, 96744, USA.
  • 6 Present Address: Chikusa Central Clinic, Imaike, Chikusa-ku, Nagoya, Aichi Pref, Japan. , (Japan)
  • 7 Center for Biomedical Research, The Queen's Medical Center, John A. Burns School of Medicine, University of Hawaii, 1301 Punchbowl St., Honolulu, HI, 96813, USA. [email protected]
  • 8 Cancer Biology Program, University of Hawaii Cancer Center, 701 Ilalo St, Honolulu, HI, -96813, USA. [email protected]
Type
Published Article
Journal
Cell communication and signaling : CCS
Publication Date
Aug 15, 2017
Volume
15
Issue
1
Pages
30–30
Identifiers
DOI: 10.1186/s12964-017-0187-9
PMID: 28810912
Source
Medline
Keywords
License
Unknown

Abstract

Early stage colon cancer proceeds independent of systemic Mg2+ status and TRPM7, and waixenicin A is a useful pharmacological tool to study of TRPM7 in vitro and in vivo.

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