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Inhibition of TLR ligand- and interferon gamma-induced murine microglial activation by Panax notoginseng.

Authors
Type
Published Article
Journal
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Publication Date
Volume
7
Issue
2
Pages
465–476
Identifiers
DOI: 10.1007/s11481-011-9333-0
PMID: 22183805
Source
Medline
License
Unknown

Abstract

Among the many products which influence microglial activation and resulting neuroinflammation, herbal medicine has recently drawn much attention due to its immunomodulatory and neuroprotective activities. The purpose of the current study was to investigate the effects of an extract of Panax notoginseng (NotoG™) on TLR ligand- and IFNγ-induced activation in N9 and EOC20 microglial cells lines. NotoG suppressed microglial activation as measured by reduced expression of accessory molecules (CD40 and CD86), decreased production of inflammatory mediators (IL-6 and TNFα), and diminished release of antibacterial products (nitric oxide). Furthermore, this immunosuppressive activity was neither dependent on the glucocorticoid receptor, nor the result of a single ginsenosides (Rb1, Rg1, or Re), which are the major active constituents of the whole extract. NotoG and select ginsenosides may therefore be of therapeutic benefit in treating or preventing neurodegenerative diseases such as multiple sclerosis and parkinson's disease.

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