Inhibition of prostaglandin biosynthesis by eicosapentaenoic acid.
- Authors
- Type
- Published Article
- Journal
- Prostaglandins and Medicine
- Publisher
- Elsevier
- Publication Date
- Nov 01, 1979
- Volume
- 3
- Issue
- 5
- Pages
- 269–278
- Identifiers
- PMID: 121610
- Source
- Medline
- License
- Unknown
Abstract
Eicosapentaenoic acid [20 : 5 (n-3)] is not oxidized by the purified cyclooxygenase from sheep vesicular glands in the conditions of low peroxide tone in which arachidonate [20 : 4 (n-6)] is rapidly oxygenated. When the level of peroxide in incubation mixtures is allowed to rise, there is a dramatic change in reactivity of the cyclooxygenase to react with 20 : 5 (n-3) at one-halt the rate and one-third the extent observed with 20 : 4 (n-6). Overall, the low peroxide levels expected in vivo would most probably cause the (n-3) type of fatty acid to be a general inhibitor of prostaglandin formation, through both reversible and irreversible actions at the enzyme site.