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Inhibition of platelet aggregation by alpha1-acid glycoprotein.

Authors
  • Snyder, S
  • Coodley, E L
Type
Published Article
Journal
Archives of Internal Medicine
Publisher
American Medical Association
Publication Date
Jul 01, 1976
Volume
136
Issue
7
Pages
778–781
Identifiers
PMID: 938167
Source
Medline
License
Unknown

Abstract

In view of known abnormalities of plasma proteins in diseases showing changes in platelet aggregation, the effect of one of the major serum proteins, alpha1-acid glycoprotein, on platelet aggregation was evaluated. This protein, when added to platelet-rich plasma, markedly inhibited platelet aggregation induced by both adenosine diphosphate (ADP) and epinephrine. Transferrin, similarly studied, had no effect. These results are consistent with the hypothesis that the relative concentration of alpha1-acid glycoprotein may influence platelet aggregation in diseases associated with abnormal concentrations of this protein.

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