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Inhibition of platelet activation in rats with severe congestive heart failure by a novel endothelial nitric oxide synthase transcription enhancer.

Authors
  • Schäfer, Andreas
  • Fraccarollo, Daniela
  • Widder, Julian
  • Eigenthaler, Martin
  • Ertl, Georg
  • Bauersachs, Johann
Type
Published Article
Journal
European journal of heart failure
Publication Date
Apr 01, 2009
Volume
11
Issue
4
Pages
336–341
Identifiers
DOI: 10.1093/eurjhf/hfp005
PMID: 19193626
Source
Medline
License
Unknown

Abstract

Platelet activation was evident in CHF rats. Therapy with the eNOS-transcription enhancer, AVE9488, reduced platelet activation in parallel to normalization of platelet NO bioavailability.

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