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Inhibition of PKC-θ preserves cardiac function and reduces fibrosis in streptozotocin-induced diabetic cardiomyopathy.

Authors
  • Li, Zhao
  • Abdullah, Chowdhury S
  • Jin, Zhu-Qiu
Type
Published Article
Journal
British Journal of Pharmacology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Jun 01, 2014
Volume
171
Issue
11
Pages
2913–2924
Identifiers
DOI: 10.1111/bph.12621
PMID: 24641494
Source
Medline
Keywords
License
Unknown

Abstract

Inhibition of PKC-θ improves cardiac function and reduces cardiac fibrosis in WT mice with streptozotocin-induced diabetes. Mature T-cells play a key role in pathophysiology of diabetic cardiomyopathy.

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