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Inhibition of Phytosterol Biosynthesis by Azasterols

Authors
  • darnet, sylvain
  • martin, laetitia
  • mercier, pierre
  • bracher, franz
  • geoffroy, philippe
  • schaller, hubert
Publication Date
Mar 02, 2020
Identifiers
DOI: 10.3390/molecules25051111
OAI: oai:mdpi.com:/1420-3049/25/5/1111/
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

Inhibitors of enzymes in essential cellular pathways are potent probes to decipher intricate physiological functions of biomolecules. The analysis of Arabidopsis thaliana sterol profiles upon treatment with a series of azasterols reveals a specific in vivo inhibition of SMT2, a plant sterol-C-methyltransferase acting as a branch point between the campesterol and sitosterol biosynthetic segments in the pathway. Side chain azasteroids that modify sitosterol homeostasis help to refine its particular function in plant development.

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