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Inhibition of phosphoglucomutase by fructose 2,6-bisphosphate.

Authors
  • Bartrons, R
  • Carreras, M
  • Climent, F
  • Carreras, J
Type
Published Article
Journal
Biochimica et Biophysica Acta
Publisher
Elsevier
Publication Date
Sep 27, 1985
Volume
842
Issue
1
Pages
52–55
Identifiers
PMID: 2931119
Source
Medline
License
Unknown

Abstract

Fructose 2,6-bisphosphate inhibits phosphoglucomutase. The inhibition is mixed with respect to glucose 1,6-bisphosphate and non-competitive with respect to glucose 1-phosphate. In contrast with fructose 1,6-bisphosphate and glycerate 1,3-bisphosphate, which also possess inhibitory effect, fructose 2,6-bisphosphate does not phosphorylate phosphoglucomutase. Fructose 2,6-bisphosphate preparations contain contaminants which can explain artefactual results previously reported.

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