Inhibition of PC cell-derived growth factor (PCDGF)/granulin-epithelin precursor (GEP) decreased cell proliferation and invasion through downregulation of cyclin D and CDK 4 and inactivation of MMP-2

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Inhibition of PC cell-derived growth factor (PCDGF)/granulin-epithelin precursor (GEP) decreased cell proliferation and invasion through downregulation of cyclin D and CDK 4 and inactivation of MMP-2

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BioMed Central
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PMC
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  • Biology
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Abstract

1471-2407-7-22.fm ral ss BioMed CentBMC Cancer Open AcceResearch article Inhibition of PC cell-derived growth factor (PCDGF)/granulin-epithelin precursor (GEP) decreased cell proliferation and invasion through downregulation of cyclin D and CDK 4 and inactivation of MMP-2 Yulan Liu†, Ling Xi†, Guoning Liao, Wei Wang, Xun Tian, Beibei Wang, Gang Chen, Zhiqiang Han, Mingfu Wu, Shixuan Wang, Jianfeng Zhou, Gang Xu, Yunping Lu and Ding Ma* Address: Cancer Biology Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P. R. China Email: Yulan Liu - [email protected]; Ling Xi - [email protected]; Guoning Liao - [email protected]; Wei Wang - [email protected]; Xun Tian - [email protected]; Beibei Wang - [email protected]; Gang Chen - [email protected]; Zhiqiang Han - [email protected]; Mingfu Wu - [email protected]; Shixuan Wang - [email protected]; Jianfeng Zhou - [email protected]; Gang Xu - [email protected]; Yunping Lu - [email protected]; Ding Ma* - [email protected] * Corresponding author †Equal contributors Abstract Background: PC cell-derived growth factor (PCDGF), also called epithelin/granulin precursor (GEP), is an 88- kDa secreted glycoprotein with the ability to stimulate cell proliferation in an autocrine fashion. In addition, some studies indicated that PCDGF participated in invasion, metastasis and survival of cancer cells by regulating cell migration, adhesion and proliferation. Yet the effects of PCDGF on proliferation and invasion of ovarian cancer cells in vitro and the mechanisms by which PCDGF mediates biological behaviors of ovarian cancer have rarely been reported. In the present study we investigated whether and how PCDGF/GEP mediated cell proliferation and invasion in ovarian cancer. Methods: PCDGF/GEP expression level in three human ovarian cancer cell lines of different invasion potential were detected by RT-PCR and western bl

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