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THE INHIBITION OF NICOTINAMIDE-ADENINE DINUCLEOTIDE-LINKED 3-ALPHA-HYDROXY STEROID DEHYDROGENASE BY CERTAIN ANTIMETABOLIC DRUGS.

Authors
  • LAMBE, R F
  • WILLIAMS, D C
Type
Published Article
Journal
The Biochemical journal
Publication Date
Jun 01, 1965
Volume
95
Pages
847–850
Identifiers
PMID: 14342524
Source
Medline
Keywords
License
Unknown

Abstract

1. The inhibition of NAD-linked 3alpha-hydroxy steroid dehydrogenase in vitro by some of the more therapeutically effective antimetabolic drugs has been investigated. 2. Antipurine and antifolic acid drugs inhibit this system, as does folic acid. 3. Combinations of antifolic acid drugs and folic acid itself produce an additive but not synergic inhibition. 4. Antimetabolic drugs give inhibitions that are additive to those produced by antagonistic steroid hormones.

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