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Inhibition of K+ currents by homocysteine in rat ventricular myocytes.

Authors
  • Shontz, R D
  • Xu, Z
  • Patel, K P
  • Rozanski, G J
Type
Published Article
Journal
Journal of cardiovascular electrophysiology
Publication Date
Feb 01, 2001
Volume
12
Issue
2
Pages
175–182
Identifiers
PMID: 11232616
Source
Medline
License
Unknown

Abstract

These data suggest that homocysteine and its oxidized form homocystine acutely inhibit I(to) channels in ventricular myocytes by mechanisms involving the free thiol or disulfide moieties of these compounds. High homocysteine or homocystine levels may contribute to abnormal repolarization and arrhythmogenic conditions in the intact heart.

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