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Inhibition of herpes simplex virus infection by tannins and related compounds.

Authors
  • Fukuchi, K1
  • Sakagami, H
  • Okuda, T
  • Hatano, T
  • Tanuma, S
  • Kitajima, K
  • Inoue, Y
  • Inoue, S
  • Ichikawa, S
  • Nonoyama, M
  • 1 First Department of Biochemistry, School of Medicine, Showa University, Tokyo, Japan. , (Japan)
Type
Published Article
Journal
Antiviral Research
Publisher
Elsevier
Publication Date
Jan 01, 1989
Volume
11
Issue
5-6
Pages
285–297
Identifiers
PMID: 2552915
Source
Medline
License
Unknown

Abstract

Several chemically defined plant extracts were investigated for their antiviral action on herpes simplex virus (HSV-1, HSV-2)-infected African green monkey kidney cells and human adenocarcinoma cells, using a plaque formation assay. Among them, the monomeric hydrolyzable tannins, oligomeric ellagitannins and condensed tannins, having galloyl groups or hexahydroxydiphenoyl groups, had the most potent anti-HSV activity. Their 50% effective doses (0.03-0.1 microgram/ml) were by two-three orders of magnitude lower than their 50% cytotoxic doses (greater than 10 micrograms/ml). On the other hand, gallic acid, neutral polysaccharides, chemically modified (N,N-dimethylaminoethyl-, carboxymethyl-, and sulfated-) glucans, sialic acid-rich glycoproteins, and uronic acid-rich pine cone polysaccharide showed little or no activity. Using radiolabeled virus particles, we demonstrated that the anti-HSV effect of the tannins is due to inhibition of virus adsorption to the cells.

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