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Inhibition of hepatitis B virus production associated with high levels of intracellular viral DNA intermediates in iron-depleted HepG2.2.15 cells.

Authors
  • Chouteau, P
  • Le Seyec, J
  • Saulier-Le Dréan, B
  • Cannie, I
  • Brissot, P
  • Lescoat, G
  • Guguen-Guillouzo, C
  • Gripon, P
Type
Published Article
Journal
Journal of Hepatology
Publisher
Elsevier
Publication Date
Jan 01, 2001
Volume
34
Issue
1
Pages
108–113
Identifiers
PMID: 11211885
Source
Medline
License
Unknown

Abstract

These results strongly suggest that iron depletion affects the HBV life cycle indirectly through the cell cycle arrest and directly through the inhibition of the viral DNA secretion. They also indicate the need to re-evaluate with caution the iron depletion protocols on HBV infected patients since a decrease of viral markers in the serum following iron-depletion may not reflect a decrease of viral replicative forms, but on the contrary, could be associated with active viral DNA synthesis.

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