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Inhibition of HBsAg secretion from Alexander cell line by Phyllanthus amarus.

Authors
  • Jayaram, S
  • Thyagarajan, S P
Type
Published Article
Journal
Indian journal of pathology & microbiology
Publication Date
Jul 01, 1996
Volume
39
Issue
3
Pages
211–215
Identifiers
PMID: 8972151
Source
Medline
License
Unknown

Abstract

Alexander cell line, an human hepatocellular carcinoma derived cell line which has the property of secreting HBsAg in the supernatant was used to study the antiviral property of phyllanthus amarus. Aquous extract of Phyllanthus amarus was evaluated for its in vitro ability to inhibit HBsAg secretion on a dose dependent manner. It was seen that P. amarus at 1mg/ml concentration on a single dose inhibited the secretion of HBsAg for a period of 48 hours. This experiment proved the anti hepatitis B virus property of P. amarus at cellular level and further confirmed its beneficial use in the treatment of acute and chronic hepatitis B and healthy carriers of HBV.

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