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Inhibition of gastric and intestinal motor activity in dogs by (Gln4) neurotensin.

Authors
  • Andersson, S
  • Rosell, S
  • Hjelmquist, U
  • Chang, D
  • Folkers, K
Type
Published Article
Journal
Acta physiologica Scandinavica
Publication Date
Jun 01, 1977
Volume
100
Issue
2
Pages
231–235
Identifiers
PMID: 888712
Source
Medline
License
Unknown

Abstract

The action of (Gln4)-neurotensin was studied on the spontaneous motor activity in isolated canine fundic, antral and intestinal pouches. All pouches had been prepared more than 6 months prior to the experiments. Spontaneous motor activity was recorded for at least 1 h before the Gln4)-neurotensin was infused i.v. for 30 min in doses ranging between 6.3 and 100 ng X kg-1 X min-1. In the vagally denervated fundic pouches (Gln4)-neurotensin inhibted motor activity in doses above 25 ng X kg-1 X min-1. The vagally innervated antral pouches were more sentitive than the vagally denervated fundic pouches to the action of (Gln4)-neurotensin. Thus motor inhibition was induced by doses as low as 6.3 ng X kg-1 X min-1. The effect of (Gln4)-neurotensin on motor activity in intestinal pouches was inconsistent. Inhibition was seen in 1 out of 7 expts. The present results show that the gastric motor activity is the most sensitive function to (Gln4)-neurotensin so far studied.

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