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Inhibition of the expression of hepatitis A and B viruses (HAV and HBV) proteins by interferon in a human hepatocarcinoma cell line (PLC/PRF/5).

Authors
Type
Published Article
Journal
Journal of Hepatology
0168-8278
Publisher
Elsevier
Publication Date
Volume
25
Issue
1
Pages
15–19
Identifiers
PMID: 8836896
Source
Medline

Abstract

Considering the absence of cytotoxic effects from the doses used, this study confirms the relevance of this cellular model for the study of antiviral cytokines in vitro. It also provides a further rationale for the clinical evaluation of the therapeutic potential of interferons in severe hepatitis cases due either to hepatitis A virus alone or to superinfection of hepatitis B virus carriers by hepatitis A virus.

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