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Inhibition of experimental vasospasm in rats with the periadventitial administration of ibuprofen using controlled-release polymers.

Authors
Type
Published Article
Journal
Stroke; a journal of cerebral circulation
Publication Date
Volume
30
Issue
1
Pages
140–147
Identifiers
PMID: 9880402
Source
Medline
License
Unknown

Abstract

The periadventitial, controlled release of ibuprofen from surgically implanted polymers significantly inhibits chronic posthemorrhagic vasospasm in this model when treatment is initiated within 6 hours of blood exposure. Vasospasm inhibition with ibuprofen correlates with a significant decrease in the number of macrophages and granulocytes in the periadventitial space. This study supports the hypothesis that inflammation mediates in part the chronic phase of posthemorrhagic vasospasm and suggests a potential alternative treatment for this condition.

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