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Inhibition of endotoxin-induced uveitis and potentiation of local TNF-alpha and interleukin-6 mRNA expression by interleukin-13.

Authors
  • Marie, O
  • Thillaye-Goldenberg, B
  • Naud, M C
  • de Kozak, Y
Type
Published Article
Journal
Investigative Ophthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
Sep 01, 1999
Volume
40
Issue
10
Pages
2275–2282
Identifiers
PMID: 10476793
Source
Medline
License
Unknown

Abstract

Interleukin-13 treatment inhibits LPS-induced ocular inflammation with inhibition of nitrite release and increased TNF and IL-6 production in the eye. These results confirm the role of the NO pathway in the pathogenesis of EIU and suggest the involvement of TNF and IL-6 in the downregulation of ocular inflammation.

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