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Inhibition of beta-amyloid aggregation and neurotoxicity by complementary (antisense) peptides.

Authors
  • Heal, Jonathan R
  • Roberts, Gareth W
  • Christie, Gary
  • Miller, Andrew D
Type
Published Article
Journal
Chembiochem : a European journal of chemical biology
Publication Date
Jan 04, 2002
Volume
3
Issue
1
Pages
86–92
Identifiers
PMID: 17590958
Source
Medline
License
Unknown

Abstract

Complementary peptides are coded for by the nucleotide sequence (read 5'-->3') of the complementary strand of DNA. By reading the sequence of complementary DNA in the 3'-->5' direction, alternative complementary peptides may be derived. We describe the derivation, testing and analysis of six complementary peptides designed against beta-amyloid peptide 1-40 (Abeta, 40). Data is presented to show that one peptide, designated 3' -->5' betaCP1-15, binds specifically to Abeta 1-40, and inhibits both fibrilisation and neurotoxicity in vitro. This suggests that complementary peptides could be useful leads for drug discovery, especially where diseases of protein misfolding are concerned.

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