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Inhibition of alpha-chymotrypsin with thiol-bearing substrate analogues in the presence of zinc ion.

Authors
  • Han, Min Su
  • Oh, Dong Ju
  • Kim, Dong H
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Feb 09, 2004
Volume
14
Issue
3
Pages
701–705
Identifiers
PMID: 14741272
Source
Medline
License
Unknown

Abstract

We have demonstrated that thiol-bearing analogues of alpha-chymotrysin (alpha-CT) substrates such as (S)-(1-benzyl-2-thiolethyl)-carbamic acid, benzyl ester (3) inhibits alpha-CT, a prototypical serine protease, in the presence of Zn(II) ion. They constitute a novel class of small molecule inhibitors for alpha-CT believed to inhibit the enzyme by forming a ternary complex consisting of alpha-CT, Zn(II) ion, and the inhibitor.

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