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Inhibition of Adipocyte Differentiation by cMyc Is Not Accompanied by Alterations in Cell Cycle Control

Authors
  • Heath, Victoria J.
  • Gillespie, David A.F.
  • Crouch, Dorothy H.
Type
Published Article
Journal
Biochemical and Biophysical Research Communications
Publication Date
Jan 01, 2000
Volume
269
Issue
2
Pages
438–443
Identifiers
DOI: 10.1006/bbrc.2000.2316
Source
Elsevier
Keywords
License
Unknown

Abstract

Using a preadipocyte cell line constitutively expressing cMyc, we set out to determine if the ability of cMyc to inhibit adipogenic differentiation was functionally distinct from its role in cell cycle progression and transformation. We now report that in this system differentiation control and cellular transformation are separable functions of cMyc. Furthermore, the Myc-induced inhibition of adipocyte differentiation appears to be mediated via suppression of C/EBP-α and p21 gene expression late in the adipogenic differentiation programme, without deregulation of either cell cycle control or gene expression during the early stages of the process.

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