Affordable Access

deepdyve-link
Publisher Website

Inhibin/activin-betaE subunit is expressed in normal and pathological human placental tissue including chorionic carcinoma cell lines.

Authors
  • Gingelmaier, Andrea
  • Brüning, Ansgar
  • Kimmich, Tanja
  • Makovitzky, Josef
  • Bergauer, Florian
  • Schiessl, Barbara
  • Friese, Klaus
  • Mylonas, Ioannis
Type
Published Article
Journal
Archives of gynecology and obstetrics
Publication Date
Feb 01, 2011
Volume
283
Issue
2
Pages
223–230
Identifiers
DOI: 10.1007/s00404-009-1340-5
PMID: 20052482
Source
Medline
License
Unknown

Abstract

We demonstrated that inhibin-betaE is expressed in normal and pathological human placenta tissues. Although the precise role of this novel inhibin subunit for human placenta development is quite unclear, similarities with the well-characterized betaA- and betaB-subunits suggest an involvement in autocrine/paracrine signaling pathways, angiogenesis, decidualization and tissue remodeling under normal as well as malignant conditions. Additionally, the human chorionic carcinoma cell lines JEG and BeWo synthesize this subunit and therefore can be used as a cell culture model for further functional analysis of this subunit in human placental tissue.

Report this publication

Statistics

Seen <100 times