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Inherited epigenetic variation--revisiting soft inheritance.

Authors
  • Richards, Eric J
Type
Published Article
Journal
Nature reviews. Genetics
Publication Date
May 01, 2006
Volume
7
Issue
5
Pages
395–401
Identifiers
PMID: 16534512
Source
Medline
License
Unknown

Abstract

Phenotypic variation is traditionally parsed into components that are directed by genetic and environmental variation. The line between these two components is blurred by inherited epigenetic variation, which is potentially sensitive to environmental inputs. Chromatin and DNA methylation-based mechanisms mediate a semi-independent epigenetic inheritance system at the interface between genetic control and the environment. Should the existence of inherited epigenetic variation alter our thinking about evolutionary change?

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