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Inhaled carbon monoxide suppresses the development of postoperative ileus in the murine small intestine.

Authors
  • Moore, Beverley A
  • Otterbein, Leo E
  • Türler, Andreas
  • Choi, Augustine M K
  • Bauer, Anthony J
Type
Published Article
Journal
Gastroenterology
Publisher
Elsevier
Publication Date
Feb 01, 2003
Volume
124
Issue
2
Pages
377–391
Identifiers
PMID: 12557144
Source
Medline
License
Unknown

Abstract

These findings suggest that CO attenuates postoperative ileus by inhibiting selective elements within the inflammatory cascade and by enhanced induction of the anti-inflammatory cytokine IL-10. In addition, the early and enhanced induction of HO-1 potentially amplifies the anti-inflammatory effects of the HO-1 pathway by protection from free radical stress and by increasing the tissue availability of CO directly at the sites of inflammation.

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