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The infusion of trieicosapentaenoyl-glycerol into humans and the in vivo formation of prostaglandin I 3 and thromboxane A 3

Authors
  • Hamazaki, T.
  • Fischer, S.
  • Schweer, H.
  • Meese, C.O.
  • Urakaze, M.
  • Yokoyama, A.
  • Yano, S.
Type
Published Article
Journal
Biochemical and Biophysical Research Communications
Publication Date
Jan 01, 1988
Volume
151
Issue
3
Pages
1386–1394
Identifiers
DOI: 10.1016/S0006-291X(88)80516-3
Source
Elsevier
Keywords
License
Unknown

Abstract

Thirty ml of an emulsion containing 3 g of trieicosapentaenoylglycerol (90 % pure, containing 5 % arachidonic acid (AA)) was infused intravenously in 2 male healthy volunteers. Urine samples were collected for 24 h before and 48 h after the infusion in 5 periods. Urinary metabolites of prostaglandin (PG) I 2/3 and thromboxane (TX) A 2/3 (PGI 2/3-M and TXB 2/3-M, respectively) were extracted from the urinary samples and measured by GC-MS. Excretion of PGI 3-M was markedly enhanced right after the infusion. Because PGI 3 was produced without involvement of intestinal absorption of eicosapentaenoic acid (EPA), enhanced PGI 3 formation was strongly suggested to take place in the vasculature. From the marked increment in TXB 2/3-M after the infusion it was calculated that conversion rate of EPA to TXA 3 was 8 % of that of AA to TXA 2 in this in vivo condition.

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