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Influenza A virus infection of human middle ear cells in vitro.

Authors
Type
Published Article
Journal
The Laryngoscope
0023-852X
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
110
Issue
10 Pt 1
Pages
1739–1744
Identifiers
PMID: 11037837
Source
Medline

Abstract

Primary cultures of human middle ear mucosal cells have been established. Two distinctly different cell culture systems have been developed: 1) middle ear epithelial cells and 2) either dedifferentiated epithelial cells or fibroblasts. Exposure of both cell types to INF A demonstrates that each can support cellular infection and viral replication. These models should be useful for studies of the pathogenesis of virus-mediated otitis media.

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