Affordable Access

Influenza A virus infection of human middle ear cells in vitro.

Authors
  • Buchman, C A1
  • Fregien, N
  • 1 Department of Otolaryngology, University of Miami School of Medicine, Florida, USA. [email protected]
Type
Published Article
Journal
The Laryngoscope
Publication Date
Oct 01, 2000
Volume
110
Issue
10 Pt 1
Pages
1739–1744
Identifiers
PMID: 11037837
Source
Medline
License
Unknown

Abstract

Primary cultures of human middle ear mucosal cells have been established. Two distinctly different cell culture systems have been developed: 1) middle ear epithelial cells and 2) either dedifferentiated epithelial cells or fibroblasts. Exposure of both cell types to INF A demonstrates that each can support cellular infection and viral replication. These models should be useful for studies of the pathogenesis of virus-mediated otitis media.

Report this publication

Statistics

Seen <100 times