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MicroRNAs and HIV-1 Infection: Antiviral Activities and Beyond

Authors
  • Swaminathan, Gokul
  • Navas-Martín, Sonia
  • Martín-García, Julio1, 2
  • 1 Graduate Program in Microbiology and Immunology, Drexel University College of Medicine
  • 2 Department of Microbiology and Immunology, Drexel University College of Medicine
Type
Published Article
Journal
Journal of Molecular Biology
Publisher
Elsevier
Publication Date
Jan 01, 2013
Accepted Date
Dec 17, 2013
Volume
426
Issue
6
Pages
1178–1197
Identifiers
DOI: 10.1101/cshperspect.a012328
Source
Elsevier
Keywords
License
Unknown

Abstract

•Controversy persists over the expression of functional miRNAs by HIV-1.•Host miRNAs seem to modulate HIV-1 infectivity by direct and indirect mechanisms.•Perhaps as a survival strategy, HIV-1 may modulate the miRNA biogenesis pathway.•miRNA expression profiles are altered post-infection both in vitro and in vivo.•Validation and standardization are needed to clarify the roles of miRNAs in HIV-1.

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