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Influenza and sudden unexpected death: the possible role of peptide cross-reactivity

Authors
  • Kanduc, Darja
Type
Published Article
Journal
Infection International
Publisher
Sciendo
Publication Date
Jun 12, 2019
Volume
7
Issue
4
Pages
121–131
Identifiers
DOI: 10.2478/ii-2018-0023
Source
De Gruyter
Keywords
License
Green

Abstract

This study investigates the hypothesis that cross-reactions may occur between human cardiac proteins and influenza antigens, thus possibly representing the molecular mechanism underlying influenzaassociated sudden unexpected death (SUD). Using titin protein as a research model, data were obtained on (1) the occurrence of the titin octapeptide AELLVLLE or its mimic AELLVALE in influenza A virus hemagglutinin (HA) sequences; (2) the immunological potential of AELLVLLE and its mimic AELLVALE; (3) the possible role of the flanking amino acid aa) context of the two octapeptide determinants in eliciting cross-reactivity between the human cardiac titin protein and HA antigens.

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