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Influenza and the challenge for immunology

Authors
  • Doherty, Peter C1, 2
  • Turner, Stephen J1
  • Webby, Richard G2
  • Thomas, Paul G2
  • 1 University of Melbourne School of Medicine, Victoria, 3010, Australia , Victoria (Australia)
  • 2 St. Jude Children's Research Hospital, Memphis, Tennessee, 38105, USA , Memphis (United States)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Apr 18, 2006
Volume
7
Issue
5
Pages
449–455
Identifiers
DOI: 10.1038/ni1343
Source
Springer Nature
License
Yellow

Abstract

The continued westward dissemination of H5N1 influenza A viruses in avian populations and the nearly 50% mortality rate of humans infected with H5N1 are a source of great international concern. A mutant H5N1 virus with the capability to spread rapidly between humans could cause a global catastrophe. Governments have reacted by developing national response plans, stockpiling antiviral drugs and speeding up the development and approval of vaccines. Here we summarize what is known about the interaction between influenza A viruses and the mammalian host response, specifically emphasizing issues that might be of interest to the broader immunology community.

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