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Influenza B viral load analysis in patients with acute respiratory infection from a tertiary hospital in Brazil.

Authors
  • Rodrigues Guimarães Alves, Vitória1
  • Kleber de Souza Luna, Luciano1
  • Santiago Cruz, Jessica1
  • Helena Perosa, Ana2
  • Bellei, Nancy1
  • 1 Clinical Virology Laboratory, Infectious Diseases Unit, Medicine Department, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, Brazil. , (Brazil)
  • 2 Central Laboratory, São Paulo Hospital, São Paulo, Brazil. , (Brazil)
Type
Published Article
Journal
Journal of Medical Virology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Dec 05, 2019
Identifiers
DOI: 10.1002/jmv.25648
PMID: 31803951
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Currently, 2 genotypes of Influenza B viruses (IFB) are cocirculating in humans: Victoria (VIC) and Yamagata (YAM). Infection and viral load (VL) were analyzed in 105 genotyped IFB (59 VIC and 46 YAM) out of 3452 respiratory samples from immunodepressed (ID), immunocompetent (IC) including outpatients (OP) and hospitalized patients (HP) attended during 2001-2013 at São Paulo Hospital. VL (Log10 RNA copies/mL) calculation was possible in 78 samples (47 VIC, 31 YAM). The age group of 12 to 18 years presented the highest detection (14.13%). Rates of infection among groups were of 3.67% (IC), 1.68% (ID), 3.50% (OP), 0.6% (HP), and VLs varied from 2.8 to 10.13 with no difference regarding age, immune status, and disease severity. From 10 OP vaccinated against influenza, 8 (7 children, 1 ID) received a matching strain shot (VIC), and 2 a monovalent influenza A H1N1pdm09. Those patients presented a VL of 6.31 ± 1.62 (mean ± SD). IFB infection rates follow an age pattern, but VL seems not to be related to frequency or clinical outcome. IFB patients with previous immunization could point to some protection for VIC infections since there was no HP. Other immunological aspects, such as lineage infection immune priming, previous infections, and vaccinations, should be further investigated. © 2019 Wiley Periodicals, Inc.

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