Effects of reaction time, chlorine dosage, pH and temperature on the formation of disinfection byproducts (DBPs), were investigated during the chloramination of Cyclops metabolite solutions. The results showed that some species of DBPs like trichloromethane (TCM), dichloroacetic acid (DCAA) and trichloroacetic acid (TCAA) could accumulate to their respective stable values with a progressive elevation in reaction time and monochloramine concentration. And 1,1,1-2-trichloropropanone (1,1,1-TCP) content decreased correspondingly with a continuous increase of reaction time. The amounts of chloral hydrate (CH), chloropicrin (TCNM), 1,1,1-TCP and DCAA firstly increased and then decreased with increasing monochloramine doses. Higher temperature resulted in a decrease of CH, dichloroacetonitrile (DCAN), 1,1-dichloropropanone (1,1-DCP), 1,1,1-TCP, DCAA and TCAA concentration. pH affected the formation of the different DBPs distinctly. TCM accumulateded with the increase of pH under 9, and DCAA, TCAA, CH and 1,1-DCP decreased continuously with increasing pH from 5 to 10, and other DBPs had the maximum concentrations at pH 6-7.