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Influence of yeasts and of their constituents on nucleoside uptake in peritoneal murine macrophages.

Authors
  • Busolo, F
  • Palù, G
  • Conventi, L
Type
Published Article
Journal
FEMS microbiology letters
Publication Date
Dec 15, 1991
Volume
69
Issue
1
Pages
5–9
Identifiers
PMID: 1783283
Source
Medline
License
Unknown

Abstract

A marked reduction of [3H]-uridine uptake was observed when mouse peritoneal macrophages (pM phi) were exposed to heat-killed Candida albicans or Saccharomyces cerevisiae. By contrast, an increased nucleoside uptake was promoted by yeast products such as zymosan, laminarin, or yeast cell-wall extracts, which are mainly composed of beta-glucans and alpha-mannans. In a search for the active fungal component(s), the uptake process was shown to be differently affected by monosaccharides and polysaccharides. These findings support the view that a specific recognition of a pM phi membrane receptor is mediating the effect of the various substances.

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