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Influence of variations in CCL3L1 and CCR5 on tuberculosis in a northwestern Colombian population.

Authors
Type
Published Article
Journal
The Journal of Infectious Diseases
1537-6613
Publisher
Oxford University Press
Publication Date
Volume
203
Issue
11
Pages
1590–1594
Identifiers
DOI: 10.1093/infdis/jir145
PMID: 21592988
Source
Medline
License
Unknown

Abstract

We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis. Furthermore, CCR5-HHD was associated with higher CCR5 gene and surface expression. These results substantiate the strong link between the pro-inflammatory effects of CCR5 and its ligands with active tuberculosis and suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addition to HIV/AIDS.

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