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Influence of tumor cell culture supernatants on macrophage functional polarization: in vitro models of macrophage-tumor environment interaction.

Authors
  • Caras, Iuliana
  • Tucureanu, Catalin
  • Lerescu, Lucian
  • Pitica, Ramona
  • Melinceanu, Laura
  • Neagu, Stefan
  • Salageanu, Aurora
Type
Published Article
Journal
Tumori Journal
Publisher
SAGE Publications
Publication Date
Jan 01, 2011
Volume
97
Issue
5
Pages
647–654
Identifiers
DOI: 10.1700/989.10726
PMID: 22158498
Source
Medline
License
Unknown

Abstract

The cytokine secretion patterns of these macrophages suggest that primary tumor cell culture supernatants are able to switch the macrophage phenotype or to induce functional polarization of macrophages toward a mixed M1/M2 phenotype. Conclusions. These data support the hypothesis that TAM behavior is modulated by the tumor microenvironment itself.

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