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Influence of treatment duration on audiogenic seizure susceptibility during barbiturate withdrawal in rats.

Authors
  • McGee, D H
  • Bourn, W M
Type
Published Article
Journal
Experientia
Publication Date
Jul 15, 1978
Volume
34
Issue
7
Pages
873–874
Identifiers
PMID: 566673
Source
Medline
License
Unknown

Abstract

Barbiturate withdrawal seizure susceptibility in rats increased with increasing duration of treatment during a 15-day treatment period in which the animals were given an i.p. dose of sodium barbital every 12 h. This method of producing dependence has clear advantages over previously described methods.

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