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Influence of some psychotropic drugs on the ethanol elimination by the isolated liver of rats chronically fed with ethanol.

Authors
  • Rajtar, G
  • Kleinrok, Z
Type
Published Article
Journal
Acta physiologica Polonica
Publication Date
Jan 01, 1990
Volume
41
Issue
7
Pages
1–7
Identifiers
PMID: 2136305
Source
Medline
License
Unknown

Abstract

During a 4-week period the rats received ethanol (EtOH), as their only drinking fluid, in a concentration ranging from 6% to 20%. In the period of 72 hours after EtOH withdrawal the rats received diazepam (DZP), imipramine (IMI) or caffeine (CAFF) i.p. twice a day in a 12-hours interval. In the experiments carried out on the livers isolated from these rats, we observed the diminution of the rate of EtOH elimination from the perfusate by the livers of DZP and IMI treated rats. CAFF did not change the rate of EtOH elimination.

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