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Influence of Serum Vitamin D Level in the Response of Actinic Keratosis to Photodynamic Therapy with Methylaminolevulinate

Authors
  • Moreno, Ricardo1
  • Nájera, Laura
  • Mascaraque, Marta2
  • Juarranz, Ángeles2
  • González, Salvador
  • Gilaberte, Yolanda
  • 1 Dermatology Service, Hospital Univ. del Henares, Coslada, 28822 Madrid, Spain
  • 2 Department of Cellular Biology, Universidad Autónoma de Madrid, 28049 Madrid, Spain
Type
Published Article
Journal
Journal of Clinical Medicine
Publisher
MDPI AG
Publication Date
Feb 01, 2020
Volume
9
Issue
2
Identifiers
DOI: 10.3390/jcm9020398
PMID: 32024208
PMCID: PMC7073858
Source
PubMed Central
Keywords
License
Green

Abstract

In mouse models of squamous cell carcinoma, pre-treatment with calcitriol prior to photodynamic therapy with aminolevulinic acid (ALA) enhances tumor cell death. We have evaluated the association between vitamin D status and the response of actinic keratoses to photodynamic therapy with methylaminolevulinate. Twenty-five patients with actinic keratoses on the head received one session of photodynamic therapy with methylaminolevulinate. Biopsies were taken at baseline and six weeks after treatment. Immuno-histochemical staining was performed for VDR, P53, Ki67 and β-catenin. Basal serum 25(OH)D levels were determined. Cases with a positive histological response to treatment had significantly higher serum 25(OH)D levels (26.96 (SD 7.49) ngr/mL) than those without response (18.60 (SE 7.49) ngr/mL) ( p = 0.05). Patients with a complete clinical response displayed lower basal VDR expression (35.71% (SD 19.88)) than partial responders (62.78% (SD 16.735)), ( p = 0.002). Our results support a relationship between vitamin D status and the response of actinic keratoses to photodynamic therapy with methylaminolevulinate.

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