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Influence of renal dysfunction on warfarin plasma protein binding.

Authors
Type
Published Article
Journal
Journal of clinical pharmacology
Publication Date
Volume
16
Issue
10 Pt 1
Pages
468–472
Identifiers
PMID: 977790
Source
Medline
License
Unknown

Abstract

The in vitro plasma protein binding of warfarin was evaluated by ultrafiltration in plasma from seven normal subjects and seven patients with varying degrees of renal dysfunction. The unbound, or free, warfarin fraction was twice as high in the plasma samples withdrawn from patients with renal impairment than in the samples obtained from normal volunteers. Furthermore, there was a positive correlation between the extent of renal dysfunction and the magnitude of the free warfarin fraction when either creatinine clearance, plasma creatinine, or BUN was used to estimate renal function.

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