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[Influence on pubertal reproductive function in female rats by immune challenge in early life].

Authors
  • Wu, Xue-qing1
  • Li, Xiao-feng
  • Ye, Bi-lü
  • 1 Department of Obstetrics and Gynecology, First Affiliated Hospital of Wenzhou Medical College, China. [email protected] , (China)
Type
Published Article
Journal
Zhonghua fu chan ke za zhi
Publication Date
Jun 01, 2011
Volume
46
Issue
6
Pages
441–445
Identifiers
PMID: 21781586
Source
Medline
License
Unknown

Abstract

Immunological stress during early critical developmental windows could have long dysfunctional effects on the pubertal reproductive function. It delayed puberty onset, reduced the percentage of the normal oestrous cycles, decreased follicles reserve and increased the thickness of the theca interna which might involve the up-regulation of the local ovarian sympathetic nerve activity.

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