Affordable Access

deepdyve-link
Publisher Website

Influence of posture on blink reflex prepulse inhibition induced by somatosensory inputs from upper and lower limbs.

Authors
  • Versace, V1
  • Campostrini, S2
  • Sebastianelli, L2
  • Saltuari, L3
  • Valls-Solé, J4
  • Kofler, M5
  • 1 Department of Neurorehabilitation, Hospital of Vipiteno/Sterzing, Vipiteno, Sterzing, Italy; Reasearch Unit for Neurorehabilitation of South Tyrol, Bolzano, Bozen, Italy. Electronic address: [email protected] , (Italy)
  • 2 Department of Neurorehabilitation, Hospital of Vipiteno/Sterzing, Vipiteno, Sterzing, Italy; Reasearch Unit for Neurorehabilitation of South Tyrol, Bolzano, Bozen, Italy. , (Italy)
  • 3 Reasearch Unit for Neurorehabilitation of South Tyrol, Bolzano, Bozen, Italy; Department of Neurology, Hochzirl Hospital, Zirl, Austria. , (Austria)
  • 4 EMG and Motor Control Unit, Department of Neurology, Hospital Clínic, Barcelona, Spain; IDIBAPS (Institut d'Investigació August Pi i Sunyer), Facultat de Medicina, University of Barcelona, Barcelona, Spain. , (Spain)
  • 5 Department of Neurology, Hochzirl Hospital, Zirl, Austria. , (Austria)
Type
Published Article
Journal
Gait & posture
Publication Date
Sep 01, 2019
Volume
73
Pages
120–125
Identifiers
DOI: 10.1016/j.gaitpost.2019.07.194
PMID: 31323620
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Prepulse inhibition (PPI) is a neurophysiological phenomenon whereby a weak stimulus modulates the reflex response to a subsequent strong stimulus. Its physiological purpose is to avoid interruption of sensory processing by subsequent disturbing stimuli at the subcortical level, thereby preventing undesired motor reactions. An important hub in the PPI circuit is the pedunculopontine nucleus, which is also involved in the control of posture and sleep/wakefulness. To study the effect of posture (supine versus standing) on PPI, induced by somatosensory prepulses to either upper or lower limb. PPI was measured as the percentage inhibition of the blink reflex response to electrical supraorbital nerve (SON) stimulation. Sixteen healthy volunteers underwent bilateral blink reflex recordings following SON stimulation either alone (baseline) or preceded by an electrical prepulse to the median nerve (MN) or sural nerve (SN), both in supine and standing. Stimulus intensity was 8 times sensory threshold for SON, and 2 times sensory threshold for MN and SN, respectively. Eight stimuli were applied in each condition. Baseline blink reflex parameters did not differ significantly between the two postures. Prepulse stimulation to MN and SN caused significant inhibition of R2. In supine but not in standing, R2 was significantly more inhibited by MN than by SN prepulses. In standing, SN stimulation caused significantly more inhibition of R2 than in supine, while the inhibition caused by MN prepulses did not differ significantly between postures. PPI induced by lower limb afferent input may contribute to postural control while standing. Copyright © 2019 Elsevier B.V. All rights reserved.

Report this publication

Statistics

Seen <100 times