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Influence of Oxidation Degree of Graphene Oxide on Its Nuclear Relaxivity and Contrast in MRI.

Authors
  • Mohanta, Zinia1
  • Gaonkar, Sumana K2
  • Kumar, Manoj3
  • Saini, Jitender3
  • Tiwari, Vivek4
  • Srivastava, Chandan5
  • Atreya, Hanudatta S2
  • 1 Centre for BioSystems Science and Engineering, Indian Institute of Science, Bengaluru 560012, India. , (India)
  • 2 Nuclear Magnetic Resonance Research Centre, Indian Institute of Science, Bengaluru 560012, India. , (India)
  • 3 Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru 560029, India. , (India)
  • 4 Centre for Brain Research, Indian Institute of Science, Bengaluru 560012, India. , (India)
  • 5 Department of Materials Engineering, Indian Institute of Science, Bengaluru 560012, India. , (India)
Type
Published Article
Journal
ACS Omega
Publisher
American Chemical Society (ACS)
Publication Date
Sep 08, 2020
Volume
5
Issue
35
Pages
22131–22139
Identifiers
DOI: 10.1021/acsomega.0c02220
PMID: 32923771
Source
Medline
Language
English
License
Unknown

Abstract

Graphene oxide (GO) serves as a versatile platform for various applications, with the oxygen content of GO playing an important role in governing its properties. In the present study, different GO types covering a wide range of oxidation degree were prepared using our newly developed two-step method involving ball milling of graphite followed by its oxidation to GO. In addition to the variations in their physicochemical properties, the different GO types exhibited differences in proton relaxivity due to their paramagnetic nature. Nuclear magnetic resonance spectroscopy studies showed that the degree of oxidation of GO perturbs its nuclear relaxation properties and, together with intercalated Mn2+ ions, provides large contrast variation in magnetic resonance imaging (MRI). The study for the first time reveals that the surface chemistry of GO affects its relaxivity and opens up new avenues for developing tunable GO-based contrast agents in magnetic resonance imaging for diagnostics and therapies. Copyright © 2020 American Chemical Society.

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