Influence of venous emptying on the reactive hyperemic blood flow response

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Influence of venous emptying on the reactive hyperemic blood flow response

Publisher
BioMed Central
Publication Date
Mar 14, 2007
Source
PMC
Keywords
License
Unknown

Abstract

1476-5918-6-3.fm ral ss BioMed CentDynamic Medicine Open AcceResearch Influence of venous emptying on the reactive hyperemic blood flow response Zeki Bahadir, Eric Tisdell, Arturo A Arce Esquivel, Devon A Dobrosielski and Michael A Welsch* Address: Department of Kinesiology, Louisiana State University, Baton Rouge, LA, USA Email: Zeki Bahadir - [email protected]; Eric Tisdell - [email protected]; Arturo A Arce Esquivel - [email protected]; Devon A Dobrosielski - [email protected]; Michael A Welsch* - [email protected] * Corresponding author Abstract Background: Previous research indicates that venous emptying serves as a stimulus for vasodilation in the human forearm. This suggests the importance of recognizing the potential influence of venous volume on reactive hyperemic blood flow (RHBF) following occlusion. The purpose of this study was to examine the influence of venous emptying on forearm vascular function. Methods: Forearm RHBF, venous capacitance and venous outflow were examined in 35 individuals (age = 22 ± 2 years), using mercury in-Silastic strain gauge plethysmography, at rest and following five minutes of upper arm occlusion using standard procedures (Control). In addition, the same measures were obtained following five minutes of upper arm occlusion preceded by two minutes of passive arm elevation (Pre-elevation). Results: Average resting arterial inflow was 2.42 ± 1.11 ml·100 ml-1·min-1. RHBF and venous capacitance were significantly greater during Pre-elevation compared to Control (RHBF; Pre- elevation: 23.76 ± 5.95 ml·100 ml-1 ·min-1 vs. Control: 19.33 ± 4.50; p = 0.001), (venous capacitance; Pre-elevation: 2.74 ± 0.89 % vs. Control: 2.19 ± 0.97, p = 0.001). Venous outflow did not differ between the two conditions. Conclusion: Venous emptying prior to upper arm occlusion results in a significant greater RHBF response and venous capacitance. Recognition of the influence of venous volume on RHBF is particularly important in studies focusing on arterial inflow,

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